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PWP2

GENERAL INFORMATION

Gene name

 PWP2

Gene description

 PWP2 periodic tryptophan protein homolog (yeast)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (CACO-2)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA024573
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024573

GENE INFORMATION

Gene name

 PWP2 (HGNC Symbol)

Synonyms

 EHOC-17, PWP2H, UTP1

Description

 PWP2 periodic tryptophan protein homolog (yeast) (HGNC Symbol)

Entrez gene summary

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 44107290 - 44131181

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000241945 (version 83.38)

Entrez gene

 5822

UniProt

 Q15269 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q15269

Antibodypedia

 PWP2 antibodies

PROTEIN BROWSER
PWP2-001
PWP2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PWP2-001
ENSP00000291576
ENST00000291576
Q15269 [Direct mapping]
Periodic tryptophan protein 2 homolog
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000028 [ribosomal small subunit assembly]
GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0030515 [snoRNA binding]
GO:0032040 [small-subunit processome]
GO:0034388 [Pwp2p-containing subcomplex of 90S preribosome]
GO:0044822 [poly(A) RNA binding]
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 919 aa
102.5 kDa 		No 0
PWP2-003
ENSP00000411749
ENST00000456705
C9J544 [Direct mapping]
Periodic tryptophan protein 2 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000028 [ribosomal small subunit assembly]
GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0030515 [snoRNA binding]
GO:0032040 [small-subunit processome]
GO:0034388 [Pwp2p-containing subcomplex of 90S preribosome]
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 187 aa
20.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.