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PEG10

GENERAL INFORMATION

Gene name

 PEG10

Gene description

 Paternally expressed 10

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (AF22, Hep G2, SCLC-21H)
HPA (normal tissue):Group enriched (adrenal gland, placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in placental cytotrophoblasts and adrenal gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA021324 , HPA029915 , HPA051038
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021324
HPA029915
HPA051038

GENE INFORMATION

Gene name

 PEG10 (HGNC Symbol)

Synonyms

 HB-1, KIAA1051, Mar2, Mart2, MEF3L, RGAG3

Description

 Paternally expressed 10 (HGNC Symbol)

Entrez gene summary

 This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]

Chromosome

 7

Cytoband

 q21.3

Chromosome location (bp)

 94656325 - 94669695

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000242265 (version 83.38)

Entrez gene

 23089

UniProt

 Q86TG7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86TG7

Antibodypedia

 PEG10 antibodies

PROTEIN BROWSER
PEG10-001
PEG10-002
PEG10-005
PEG10-006
PEG10-007
PEG10-008
PEG10-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PEG10-001
ENSP00000417587
ENST00000482108
Q86TG7 [Direct mapping]
Retrotransposon-derived protein PEG10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0008270 [zinc ion binding]
GO:0030154 [cell differentiation]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0044822 [poly(A) RNA binding]
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 325 aa
37 kDa 		No 0
PEG10-002
ENSP00000418944
ENST00000488574
B4DSP0 [Direct mapping]
HCG1642748, isoform CRA_b; Retrotransposon-derived protein PEG10; cDNA FLJ56638, highly similar to Homo sapiens paternally expressed 10 (PEG10), transcript variant 1, mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001890 [placenta development]
GO:0003676 [nucleic acid binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
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 401 aa
45.1 kDa 		No 0
PEG10-005
ENSP00000481101
ENST00000617526
A0A087WXK2 [Direct mapping]
Retrotransposon-derived protein PEG10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0008270 [zinc ion binding]
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 707 aa
80.1 kDa 		No 0
PEG10-006
ENSP00000480676
ENST00000612748
A0A087WX23 [Direct mapping]
Retrotransposon-derived protein PEG10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0008270 [zinc ion binding]
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 783 aa
88.2 kDa 		No 0
PEG10-007
ENSP00000482653
ENST00000615790
A0A087WZG9 [Direct mapping]
Retrotransposon-derived protein PEG10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0008270 [zinc ion binding]
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 359 aa
40.5 kDa 		No 0
PEG10-008
ENSP00000478744
ENST00000612941
A0A087WUL4 [Direct mapping]
Retrotransposon-derived protein PEG10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0008270 [zinc ion binding]
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 741 aa
83.6 kDa 		No 0
PEG10-009
ENSP00000482046
ENST00000613043
A0A087WYS2 [Direct mapping]
Retrotransposon-derived protein PEG10
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 31 aa
3.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.