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MRPL20

GENERAL INFORMATION

Gene name

 MRPL20

Gene description

 Mitochondrial ribosomal protein L20

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA047074
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047074

GENE INFORMATION

Gene name

 MRPL20 (HGNC Symbol)

Synonyms

 FLJ10024

Description

 Mitochondrial ribosomal protein L20 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.33

Chromosome location (bp)

 1401908 - 1407313

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000242485 (version 83.38)

Entrez gene

 55052

UniProt

 Q9BYC9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYC9

Antibodypedia

 MRPL20 antibodies

PROTEIN BROWSER
MRPL20-001
MRPL20-003
MRPL20-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPL20-001
ENSP00000341082
ENST00000344843
Q9BYC9 [Direct mapping]
39S ribosomal protein L20, mitochondrial
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000027 [ribosomal large subunit assembly]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0019843 [rRNA binding]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 149 aa
17.4 kDa 		No 0
MRPL20-003
ENSP00000460924
ENST00000482352
Q9BYC9 [Direct mapping]
39S ribosomal protein L20, mitochondrial
Show all
Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000027 [ribosomal large subunit assembly]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005743 [mitochondrial inner membrane]
GO:0005761 [mitochondrial ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0019843 [rRNA binding]
GO:0032543 [mitochondrial translation]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
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 155 aa
18.1 kDa 		No 0
MRPL20-004
ENSP00000459994
ENST00000492508
I3L2X1 [Direct mapping]
39S ribosomal protein L20, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0019843 [rRNA binding]
Show all
 66 aa
7.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.