Expression of ARPIN in cancer - Summary - The Human Protein Atlas

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ARPIN

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARPIN
Gene description	Actin-related protein 2/3 complex inhibitor
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 3 antibodies. HPA040513 , HPA047173 , HPA052278
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040513	HPA047173	HPA052278

GENE INFORMATION
Gene name	ARPIN (HGNC Symbol)
Synonyms	C15orf38, MGC61550
Description	Actin-related protein 2/3 complex inhibitor (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	89895006 - 89912956
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000242498 (version 83.38)
Entrez gene	348110
UniProt	Q7Z6K5 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z6K5
Antibodypedia	ARPIN antibodies

PROTEIN BROWSER

ARPIN-001	ARPIN-002	ARPIN-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARPIN-001 ENSP00000350075 ENST00000357484	Q7Z6K5 [Direct mapping] Arpin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0030027 [lamellipodium] GO:0030336 [negative regulation of cell migration] GO:0033058 [directional locomotion] GO:0051126 [negative regulation of actin nucleation] GO:2000393 [negative regulation of lamellipodium morphogenesis] Show all	226 aa 24.9 kDa	No	0
ARPIN-002 ENSP00000453687 ENST00000460685	H0YMP5 [Direct mapping] Arpin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		130 aa 14.1 kDa	No	0
ARPIN-003 ENSP00000453006 ENST00000560096	H0YL03 [Direct mapping] Arpin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 14.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.