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CNTF

GENERAL INFORMATION

Gene name

 CNTF

Gene description

 Ciliary neurotrophic factor

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (fallopian tube)
FANTOM5:Tissue enhanced (adipose tissue, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA019654
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (fallopian tube)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, retina)

GENE INFORMATION

Gene name

 CNTF (HGNC Symbol)

Synonyms

 HCNTF

Description

 Ciliary neurotrophic factor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 58622673 - 58625733

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000242689 (version 83.38)

Entrez gene

 1270

UniProt

 P26441 (UniProt - Evidence at protein level)

neXtProt

 NX_P26441

Antibodypedia

 CNTF antibodies

PROTEIN BROWSER
CNTF-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNTF-001
ENSP00000355370
ENST00000361987
P26441 [Direct mapping]
Ciliary neurotrophic factor
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0005127 [ciliary neurotrophic factor receptor binding]
GO:0005138 [interleukin-6 receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0040007 [growth]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0046533 [negative regulation of photoreceptor cell differentiation]
GO:0046668 [regulation of retinal cell programmed cell death]
GO:0048644 [muscle organ morphogenesis]
GO:0048666 [neuron development]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
GO:0097058 [CRLF-CLCF1 complex]
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 200 aa
22.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.