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PSG11

GENERAL INFORMATION

Gene name

 PSG11

Gene description

 Pregnancy specific beta-1-glycoprotein 11

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enriched (U-2197)
HPA (normal tissue):Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 2 antibodies.
HPA042240 , HPA046327
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042240
HPA046327

GENE INFORMATION

Gene name

 PSG11 (HGNC Symbol)

Synonyms

 MGC22484, PSG13, PSG14

Description

 Pregnancy specific beta-1-glycoprotein 11 (HGNC Symbol)

Entrez gene summary

 The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

Chromosome

 19

Cytoband

 q13.31

Chromosome location (bp)

 43007656 - 43026512

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000243130 (version 83.38)

Entrez gene

 5680

UniProt

 Q9UQ72 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UQ72

Antibodypedia

 PSG11 antibodies

PROTEIN BROWSER
PSG11-001
PSG11-004
PSG11-005
PSG11-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PSG11-001
ENSP00000319140
ENST00000320078
Q9UQ72 [Direct mapping]
Pregnancy-specific beta-1-glycoprotein 11
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007565 [female pregnancy]
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 335 aa
37.1 kDa 		Yes 0
PSG11-004
ENSP00000385427
ENST00000403486
Q9UQ72 [Direct mapping]
Pregnancy-specific beta-1-glycoprotein 11
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007565 [female pregnancy]
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 213 aa
23.4 kDa 		No 0
PSG11-005
ENSP00000304913
ENST00000306322
Q9UQ72 [Direct mapping]
Pregnancy-specific beta-1-glycoprotein 11
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007565 [female pregnancy]
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 213 aa
23.4 kDa 		No 0
PSG11-011
ENSP00000472372
ENST00000598133
M0R276 [Direct mapping]
Pregnancy-specific beta-1-glycoprotein 11
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 320 aa
36.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.