Expression of PSG4 in cancer - Summary - The Human Protein Atlas

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PSG4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PSG4
Gene description	Pregnancy specific beta-1-glycoprotein 4
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (U-2197)
HPA (normal tissue):	Group enriched (parathyroid gland, placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA046327
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046327

GENE INFORMATION
Gene name	PSG4
Synonyms
Description	Pregnancy specific beta-1-glycoprotein 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a pregnancy-specific glycoprotein (PSG), one of several encoded by a cluster of similar genes on chromosome 19. This gene is a member of the carcinoembryonic antigen (CEA) gene family and may play a role in regulation of the innate immune system. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Chromosome	19
Cytoband	q13.31
Chromosome location (bp)	43192702 - 43207299
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000243137 (version 83.38)
Entrez gene	5672
UniProt	Q00888 (UniProt - Evidence at transcript level)
neXtProt	NX_Q00888
Antibodypedia	PSG4 antibodies

PROTEIN BROWSER

PSG4-001	PSG4-003	PSG4-004	PSG4-006	PSG4-008	PSG4-009	PSG4-010	PSG4-011	PSG4-015	PSG4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PSG4-001 ENSP00000384770 ENST00000405312	Q00888 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007565 [female pregnancy] GO:0070062 [extracellular exosome] Show all	419 aa 47.1 kDa	Yes	0
PSG4-003 ENSP00000244295 ENST00000244295	Q00888 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007565 [female pregnancy] GO:0070062 [extracellular exosome] Show all	326 aa 36.3 kDa	Yes	0
PSG4-004 ENSP00000388134 ENST00000451895	C9JWP2 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	252 aa 28.1 kDa	No	0
PSG4-006 ENSP00000470073 ENST00000600572	M0QYU2 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	78 aa 8.8 kDa	No	0
PSG4-008 ENSP00000472818 ENST00000599371	M0R2U8 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	96 aa 10.6 kDa	No	0
PSG4-009 ENSP00000471124 ENST00000596907	M0R0B3 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	292 aa 32.8 kDa	No	0
PSG4-010 ENSP00000469547 ENST00000599746	M0QY31 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	244 aa 27.8 kDa	No	0
PSG4-011 ENSP00000472885 ENST00000599391	M0R2Y7 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	180 aa 20 kDa	No	0
PSG4-015 ENSP00000472423 ENST00000597374	M0R2A2 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	258 aa 29.3 kDa	No	0
PSG4-201 ENSP00000387864 ENST00000433626	Q00888 [Direct mapping] Pregnancy-specific beta-1-glycoprotein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007565 [female pregnancy] GO:0070062 [extracellular exosome] Show all	326 aa 36.8 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
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