Expression of AMY2A in cancer - Summary

GENERAL INFORMATION
Gene name	AMY2A
Gene description	Amylase, alpha 2A (pancreatic)
Protein class	Enzymes FDA approved drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (pancreatic cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in pancreatic exocrine glandular cells and salivary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 4 antibodies. HPA045394 , HPA045399 , HPA046980 , CAB045960
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA045394	HPA045399	HPA046980	CAB045960

GENE INFORMATION
Gene name	AMY2A (HGNC Symbol)
Synonyms	AMY2
Description	Amylase, alpha 2A (pancreatic) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the alpha-amylase family of proteins. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, catalyzing the first step in digestion of dietary starch and glycogen. This gene and several family members are present in a gene cluster on chromosome 1. This gene encodes an amylase isoenzyme produced by the pancreas. [provided by RefSeq, Jan 2015]
Chromosome	1
Cytoband	p21.1
Chromosome location (bp)	103616811 - 103625780
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000243480 (version 83.38)
Entrez gene	279
UniProt	P04746 (UniProt - Evidence at protein level)
neXtProt	NX_P04746
Antibodypedia	AMY2A antibodies

PROTEIN BROWSER

AMY2A-001	AMY2A-002	AMY2A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMY2A-001 ENSP00000397582 ENST00000414303	P04746 [Direct mapping] Pancreatic alpha-amylase Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004556 [alpha-amylase activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0016052 [carbohydrate catabolic process] GO:0031404 [chloride ion binding] GO:0043169 [cation binding] GO:0044245 [polysaccharide digestion] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	511 aa 57.7 kDa	Yes	0
AMY2A-002 ENSP00000390832 ENST00000423678	H7BZQ8 [Direct mapping] Alpha-amylase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004556 [alpha-amylase activity] GO:0005975 [carbohydrate metabolic process] GO:0043169 [cation binding] Show all	209 aa 23.5 kDa	Yes	0
AMY2A-201 ENSP00000481450 ENST00000622339	P04746 [Direct mapping] Pancreatic alpha-amylase Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004556 [alpha-amylase activity] GO:0005509 [calcium ion binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005975 [carbohydrate metabolic process] GO:0016052 [carbohydrate catabolic process] GO:0031404 [chloride ion binding] GO:0043169 [cation binding] GO:0044245 [polysaccharide digestion] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	511 aa 57.7 kDa	Yes	0