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TNFRSF6B

GENERAL INFORMATION

Gene name

 TNFRSF6B

Gene description

 Tumor necrosis factor receptor superfamily, member 6b, decoy

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (PC-3, RPTEC TERT1, TIME)
HPA (normal tissue):Tissue enriched (appendix)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in gastrointestinal tract and CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA047154
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047154

GENE INFORMATION

Gene name

 TNFRSF6B (HGNC Symbol)

Synonyms

 DcR3, M68, TR6

Description

 Tumor necrosis factor receptor superfamily, member 6b, decoy (HGNC Symbol)

Entrez gene summary

 This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 63696668 - 63698684

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000243509 (version 83.38)

Entrez gene

 8771

UniProt

 O95407 (UniProt - Evidence at protein level)

neXtProt

 NX_O95407

Antibodypedia

 TNFRSF6B antibodies

PROTEIN BROWSER
TNFRSF6B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNFRSF6B-001
ENSP00000359013
ENST00000369996
O95407 [Direct mapping]
Tumor necrosis factor receptor superfamily member 6B
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004872 [receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007275 [multicellular organismal development]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043410 [positive regulation of MAPK cascade]
GO:0097190 [apoptotic signaling pathway]
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 300 aa
32.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.