Tissue expression of WFDC6 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	WFDC6
Gene description	WAP four-disulfide core domain 6
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (epididymis, testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enriched (epididymis)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (epididymis, testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (epididymis)

GENE INFORMATION
Gene name	WFDC6 (HGNC Symbol)
Synonyms	C20orf171, dJ461P17.11, WAP6
Description	WAP four-disulfide core domain 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Read-through transcription exists between this gene and the upstream SPINLW1 (serine peptidase inhibitor-like, with Kunitz and WAP domains 1) gene. [provided by RefSeq, Nov 2010]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	45534196 - 45539495
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000243543 (version 83.38)
Entrez gene	140870
UniProt	Q9BQY6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BQY6
Antibodypedia	WFDC6 antibodies

PROTEIN BROWSER

WFDC6-001	WFDC6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WFDC6-001 ENSP00000361755 ENST00000372670	Q9BQY6 [Direct mapping] WAP four-disulfide core domain protein 6 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:0030414 [peptidase inhibitor activity] Show all	86 aa 9.7 kDa	Yes	0
WFDC6-002 ENSP00000361750 ENST00000372665	Q9BQY6 [Direct mapping] WAP four-disulfide core domain protein 6 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] GO:0030414 [peptidase inhibitor activity] Show all	131 aa 14.6 kDa	Yes	0