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UPK3B

GENERAL INFORMATION

Gene name

 UPK3B

Gene description

 Uroplakin 3B

Protein class

 Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (esophagus, lung, urinary bladder)
GTEx:Tissue enhanced (urinary bladder)
FANTOM5:Tissue enhanced (esophagus, lung, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 High membranous expression in umbrella cells in urinary bladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA010506
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, lung, urinary bladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (urinary bladder)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, lung, tonsil)

GENE INFORMATION

Gene name

 UPK3B (HGNC Symbol)

Synonyms

 FLJ32198, MGC10902, p35, UPIIIb

Description

 Uroplakin 3B (HGNC Symbol)

Entrez gene summary

 UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM, Mar 2008]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 76510428 - 76516521

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000243566 (version 83.38)

Entrez gene

 80761

UniProt

 Q9BT76 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BT76

Antibodypedia

 UPK3B antibodies

PROTEIN BROWSER
UPK3B-001
UPK3B-002
UPK3B-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UPK3B-001
ENSP00000334938
ENST00000334348
Q9BT76 [Direct mapping]
Uroplakin-3b
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005886 [plasma membrane]
GO:0010629 [negative regulation of gene expression]
GO:0016021 [integral component of membrane]
GO:0070062 [extracellular exosome]
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 276 aa
29.8 kDa 		Yes 1
UPK3B-002
ENSP00000257632
ENST00000257632
Q9BT76 [Direct mapping]
Uroplakin-3b
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005886 [plasma membrane]
GO:0010629 [negative regulation of gene expression]
GO:0016021 [integral component of membrane]
GO:0070062 [extracellular exosome]
Show all
 320 aa
33.9 kDa 		Yes 0
UPK3B-003
ENSP00000378319
ENST00000394849
Q9BT76 [Direct mapping]
Uroplakin-3b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005886 [plasma membrane]
GO:0010629 [negative regulation of gene expression]
GO:0016021 [integral component of membrane]
GO:0070062 [extracellular exosome]
Show all
 265 aa
28.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.