Expression of IL10RB in cancer - Summary - The Human Protein Atlas

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IL10RB

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL10RB
Gene description	Interleukin 10 receptor, beta
Protein class	CD markers Disease related genes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 2 antibodies. HPA047550 , CAB020670
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047550	CAB020670

GENE INFORMATION
Gene name	IL10RB (HGNC Symbol)
Synonyms	CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2
Description	Interleukin 10 receptor, beta (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q22.11
Chromosome location (bp)	33266358 - 33297234
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000243646 (version 83.38)
Entrez gene	3588
UniProt	Q08334 (UniProt - Evidence at protein level)
neXtProt	NX_Q08334
Antibodypedia	IL10RB antibodies

PROTEIN BROWSER

IL10RB-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL10RB-001 ENSP00000290200 ENST00000290200	Q08334 [Direct mapping] Interleukin-10 receptor subunit beta Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Show all	GO:0004872 [receptor activity] GO:0004920 [interleukin-10 receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032002 [interleukin-28 receptor complex] GO:0051607 [defense response to virus] GO:0070062 [extracellular exosome] Show all	325 aa 37 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.