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Malignant cells displayed moderate to strong cytoplasmic and nuclear immunoreactivity. Additional membranous staining was observed in a few squamous cell carcinomas, gastric, pancreatic, prostate and urothelial cancers. Several testicular cancers were weakly stained.
Prostate cancers showed moderate to strong cytoplasmic and membranous staining along with distinct extracellular positivity. Several cases of malignant carcinoids, colorectal, breast, endometrial, urothelial, gastric and pancreatic cancers exhibited weak to moderate cytoplasmic immunoreactivity. Remaining malignant cells were mainly negative.
GENE INFORMATION
Gene name
WDR92 (HGNC Symbol)
Synonyms
FLJ31741, Monad
Description
WD repeat domain 92 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein with two WD40 repeat domains thought to be involved in an apoptosis via activation of caspase-3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]