Cell atlas - NME2 - The Human Protein Atlas

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NME2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	NME2
Gene description	NME/NM23 nucleoside diphosphate kinase 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	NME2 (HGNC Symbol)
Synonyms	NDPKB, NM23-H2
Description	NME/NM23 nucleoside diphosphate kinase 2 (HGNC Symbol)
Entrez gene summary	Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
Chromosome	17
Cytoband	q21.33
Chromosome location (bp)	51165435 - 51171747
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000243678 (version 83.38)
Entrez gene	4831
UniProt
neXtProt
Antibodypedia	NME2 antibodies

PROTEIN BROWSER

NME2-001	NME2-002	NME2-003	NME2-004	NME2-005	NME2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NME2-001 ENSP00000421064 ENST00000512737	Q6FHN3 [Target identity:100%; Query identity:100%] Nucleoside diphosphate kinase Show all	Predicted intracellular proteins Show all	GO:0004550 [nucleoside diphosphate kinase activity] GO:0006165 [nucleoside diphosphate phosphorylation] GO:0006183 [GTP biosynthetic process] GO:0006228 [UTP biosynthetic process] GO:0006241 [CTP biosynthetic process] Show all	152 aa 17.3 kDa	No	0
NME2-002 ENSP00000426901 ENST00000503064	Q6FHN3 [Target identity:100%; Query identity:100%] Nucleoside diphosphate kinase Show all	Predicted intracellular proteins Show all	GO:0004550 [nucleoside diphosphate kinase activity] GO:0006165 [nucleoside diphosphate phosphorylation] GO:0006183 [GTP biosynthetic process] GO:0006228 [UTP biosynthetic process] GO:0006241 [CTP biosynthetic process] Show all	152 aa 17.3 kDa	No	0
NME2-003 ENSP00000426976 ENST00000514264	Q6FHN3 [Target identity:100%; Query identity:100%] Nucleoside diphosphate kinase Show all	Predicted intracellular proteins Show all	GO:0004550 [nucleoside diphosphate kinase activity] GO:0006165 [nucleoside diphosphate phosphorylation] GO:0006183 [GTP biosynthetic process] GO:0006228 [UTP biosynthetic process] GO:0006241 [CTP biosynthetic process] Show all	152 aa 17.3 kDa	No	0
NME2-004 ENSP00000425581 ENST00000513177	Q6FHN3 [Target identity:100%; Query identity:100%] Nucleoside diphosphate kinase Show all	Predicted intracellular proteins Show all	GO:0004550 [nucleoside diphosphate kinase activity] GO:0006165 [nucleoside diphosphate phosphorylation] GO:0006183 [GTP biosynthetic process] GO:0006228 [UTP biosynthetic process] GO:0006241 [CTP biosynthetic process] Show all	152 aa 17.3 kDa	No	0
NME2-005 ENSP00000376886 ENST00000393190	Q6FHN3 [Target identity:100%; Query identity:100%] Nucleoside diphosphate kinase Show all	Predicted intracellular proteins Show all	GO:0002762 [negative regulation of myeloid leukocyte differentiation] GO:0004550 [nucleoside diphosphate kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005504 [fatty acid binding] GO:0005882 [intermediate filament] GO:0006165 [nucleoside diphosphate phosphorylation] GO:0006183 [GTP biosynthetic process] GO:0006228 [UTP biosynthetic process] GO:0006241 [CTP biosynthetic process] GO:0008144 [drug binding] GO:0010976 [positive regulation of neuron projection development] GO:0019215 [intermediate filament binding] GO:0019899 [enzyme binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031966 [mitochondrial membrane] GO:0034599 [cellular response to oxidative stress] GO:0046777 [protein autophosphorylation] GO:0048471 [perinuclear region of cytoplasm] GO:0051259 [protein oligomerization] GO:0060416 [response to growth hormone] GO:0071333 [cellular response to glucose stimulus] GO:0071398 [cellular response to fatty acid] Show all	152 aa 17.3 kDa	No	0
NME2-010 ENSP00000376880 ENST00000393183	F6XY72 [Direct mapping] HCG2001850, isoform CRA_c; Nucleoside diphosphate kinase B Show all	Predicted intracellular proteins Show all	GO:0004550 [nucleoside diphosphate kinase activity] GO:0006165 [nucleoside diphosphate phosphorylation] GO:0006183 [GTP biosynthetic process] GO:0006228 [UTP biosynthetic process] GO:0006241 [CTP biosynthetic process] Show all	82 aa 9.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.