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MRPS6

GENERAL INFORMATION

Gene name

 MRPS6

Gene description

 Mitochondrial ribosomal protein S6

Protein class

 Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA007861 , HPA049676
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA007861
HPA049676

GENE INFORMATION

Gene name

 MRPS6 (HGNC Symbol)

Synonyms

 C21orf101, MRP-S6, RPMS6

Description

 Mitochondrial ribosomal protein S6 (HGNC Symbol)

Entrez gene summary

 Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.11

Chromosome location (bp)

 34073224 - 34143034

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000243927 (version 83.38)

Entrez gene

 64968

UniProt

 P82932 (UniProt - Evidence at protein level)

neXtProt

 NX_P82932

Antibodypedia

 MRPS6 antibodies

PROTEIN BROWSER
MRPS6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRPS6-001
ENSP00000382250
ENST00000399312
P82932 [Direct mapping]
28S ribosomal protein S6, mitochondrial
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Ribosomal proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005763 [mitochondrial small ribosomal subunit]
GO:0005840 [ribosome]
GO:0006412 [translation]
GO:0006996 [organelle organization]
GO:0015935 [small ribosomal subunit]
GO:0019843 [rRNA binding]
GO:0032543 [mitochondrial translation]
GO:0070124 [mitochondrial translational initiation]
GO:0070125 [mitochondrial translational elongation]
GO:0070126 [mitochondrial translational termination]
GO:0070181 [small ribosomal subunit rRNA binding]
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 125 aa
14.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.