Expression of ZNF512 in cancer - Summary - The Human Protein Atlas

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ZNF512

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZNF512
Gene description	Zinc finger protein 512
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA031430
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable), endometrial cancer (unfavourable), pancreatic cancer (favourable) and breast cancer (favourable).
Lung cancer p<0.001 Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031430

GENE INFORMATION
Gene name	ZNF512 (HGNC Symbol)
Synonyms	KIAA1805
Description	Zinc finger protein 512 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing four putative zinc finger motifs. Zinc finger motifs may bind to proteins or nucleic acids. Zinc finger-containing proteins are involved in a variety of processes, including regulation of transcription. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	27582969 - 27623215
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000243943 (version 83.38)
Entrez gene	84450
UniProt	Q96ME7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96ME7
Antibodypedia	ZNF512 antibodies

PROTEIN BROWSER

ZNF512-001	ZNF512-002	ZNF512-201	ZNF512-202	ZNF512-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNF512-001 ENSP00000347648 ENST00000355467	Q96ME7 [Direct mapping] Zinc finger protein 512 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	567 aa 64.7 kDa	No	0
ZNF512-002 ENSP00000369040 ENST00000379717	G3XAG1 [Direct mapping] Zinc finger protein 512; Zinc finger protein 512, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0046872 [metal ion binding] Show all	566 aa 64.6 kDa	No	0
ZNF512-201 ENSP00000395660 ENST00000413371	Q96ME7 [Direct mapping] Zinc finger protein 512 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	490 aa 56.4 kDa	No	0
ZNF512-202 ENSP00000407038 ENST00000416005	Q96ME7 [Direct mapping] Zinc finger protein 512 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	538 aa 61.4 kDa	No	0
ZNF512-203 ENSP00000451572 ENST00000556601	Q96ME7 [Direct mapping] Zinc finger protein 512 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	490 aa 56.4 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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