Tissue expression of UGT1A7 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	UGT1A7
Gene description	UDP glucuronosyltransferase 1 family, polypeptide A7
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (esophagus)
GTEx:	Tissue enriched (esophagus)
FANTOM5:	Group enriched (esophagus, tonsil)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (esophagus)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (esophagus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (esophagus, tonsil)

GENE INFORMATION
Gene name	UGT1A7 (HGNC Symbol)
Synonyms	UGT1G
Description	UDP glucuronosyltransferase 1 family, polypeptide A7 (HGNC Symbol)
Entrez gene summary	This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	233681938 - 233773299
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000244122 (version 83.38)
Entrez gene	54577
UniProt	Q9HAW7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HAW7
Antibodypedia	UGT1A7 antibodies

PROTEIN BROWSER

UGT1A7-001	UGT1A7-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UGT1A7-001 ENSP00000362525 ENST00000373426	Q9HAW7 [Direct mapping] UDP-glucuronosyltransferase 1-7 Q5DSZ7 [Target identity:100%; Query identity:100%] UDP-glucuronosyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001972 [retinoic acid binding] GO:0004857 [enzyme inhibitor activity] GO:0005080 [protein kinase C binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006631 [fatty acid metabolic process] GO:0007588 [excretion] GO:0008144 [drug binding] GO:0008152 [metabolic process] GO:0009804 [coumarin metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0017144 [drug metabolic process] GO:0019899 [enzyme binding] GO:0032870 [cellular response to hormone stimulus] GO:0042573 [retinoic acid metabolic process] GO:0042803 [protein homodimerization activity] GO:0043086 [negative regulation of catalytic activity] GO:0045922 [negative regulation of fatty acid metabolic process] GO:0046982 [protein heterodimerization activity] GO:0051552 [flavone metabolic process] GO:0052695 [cellular glucuronidation] GO:0052696 [flavonoid glucuronidation] GO:0052697 [xenobiotic glucuronidation] GO:1904224 [negative regulation of glucuronosyltransferase activity] GO:2001030 [negative regulation of cellular glucuronidation] Show all	530 aa 59.8 kDa	Yes	1
UGT1A7-002 ENSP00000420181 ENST00000485022	H0Y8D7 [Direct mapping] UDP-glucuronosyltransferase 1-7 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] Show all	157 aa 17.9 kDa	No	0