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P2RY11

GENERAL INFORMATION

Gene name

 P2RY11

Gene description

 Purinergic receptor P2Y, G-protein coupled, 11

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA014232
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION

Gene name

 P2RY11 (HGNC Symbol)

Synonyms

 P2Y11

Description

 Purinergic receptor P2Y, G-protein coupled, 11 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10111538 - 10115372

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000244165 (version 83.38)

Entrez gene

 5032

UniProt

 Q96G91 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q96G91

Antibodypedia

 P2RY11 antibodies

PROTEIN BROWSER
P2RY11-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
P2RY11-001
ENSP00000323872
ENST00000321826
Q96G91 [Direct mapping]
P2Y purinoceptor 11
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Adenosine and adenine nucleotide receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0001973 [adenosine receptor signaling pathway]
GO:0004872 [receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006952 [defense response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0019722 [calcium-mediated signaling]
GO:0023041 [neuronal signal transduction]
GO:0030594 [neurotransmitter receptor activity]
GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway]
GO:0045028 [G-protein coupled purinergic nucleotide receptor activity]
GO:0045031 [ATP-activated adenosine receptor activity]
GO:0071318 [cellular response to ATP]
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 374 aa
40.3 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.