Expression of LY6G6D in cancer - Summary - The Human Protein Atlas

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LY6G6D

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LY6G6D
Gene description	Lymphocyte antigen 6 complex, locus G6D
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (colorectal cancer)
HPA (cell line):	Cell line enhanced (HEL)
HPA (normal tissue):	Tissue enhanced (seminal vesicle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA054412
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (colorectal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA054412

GENE INFORMATION
Gene name	LY6G6D (HGNC Symbol)
Synonyms	C6orf23, G6D, Ly6-D, MEGT1, NG25
Description	Lymphocyte antigen 6 complex, locus G6D (HGNC Symbol)
Entrez gene summary	LY6G6D belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Apr 2009]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31715356 - 31717804
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000244355 (version 83.38)
Entrez gene	58530
UniProt	O95868 (UniProt - Evidence at protein level)
neXtProt	NX_O95868
Antibodypedia	LY6G6D antibodies

PROTEIN BROWSER

LY6G6D-001	LY6G6D-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LY6G6D-001 ENSP00000364985 ENST00000375825	O95868 [Direct mapping] Lymphocyte antigen 6 complex locus protein G6d Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0030175 [filopodium] GO:0031225 [anchored component of membrane] Show all	133 aa 13.7 kDa	Yes	1
LY6G6D-002 ENSP00000364984 ENST00000375824	F6XWZ1 [Direct mapping] Lymphocyte antigen 6 complex locus protein G6d Q8NDY2 [Target identity:100%; Query identity:100%] LY6G6D protein, isoform B Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		174 aa 18.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.