Expression of ASPRV1 in cancer - Summary

GENERAL INFORMATION
Gene name	ASPRV1
Gene description	Aspartic peptidase, retroviral-like 1
Protein class	Enzymes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (head and neck cancer, melanoma)
HPA (cell line):	Cell line enhanced (REH)
HPA (normal tissue):	Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in superficial squamous epithelium of skin and cervix.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA034809 , HPA034810
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (head and neck cancer, melanoma)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA034809	HPA034810

GENE INFORMATION
Gene name	ASPRV1 (HGNC Symbol)
Synonyms	FLJ25084, SASPase, Taps
Description	Aspartic peptidase, retroviral-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p13.3
Chromosome location (bp)	69960089 - 69962265
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000244617 (version 83.38)
Entrez gene	151516
UniProt	Q53RT3 (UniProt - Evidence at protein level)
neXtProt	NX_Q53RT3
Antibodypedia	ASPRV1 antibodies

PROTEIN BROWSER

ASPRV1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASPRV1-001 ENSP00000315383 ENST00000320256	Q53RT3 [Direct mapping] Retroviral-like aspartic protease 1 Show all	Enzymes Peptidases Aspartic-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] GO:0016485 [protein processing] GO:0043588 [skin development] Show all	343 aa 37 kDa	No	1