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UBE2V1

GENERAL INFORMATION

Gene name

 UBE2V1

Gene description

 Ubiquitin-conjugating enzyme E2 variant 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 UBE2V1 (HGNC Symbol)

Synonyms

 CROC-1, CROC1, UBE2V, UEV-1, UEV1A

Description

 Ubiquitin-conjugating enzyme E2 variant 1 (HGNC Symbol)

Entrez gene summary

 Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]

Chromosome

 20

Cytoband

 q13.13

Chromosome location (bp)

 50081124 - 50115959

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000244687 (version 83.38)

Entrez gene

 7335

UniProt

 Q13404 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13404

Antibodypedia

 UBE2V1 antibodies

PROTEIN BROWSER
UBE2V1-001
UBE2V1-002
UBE2V1-003
UBE2V1-004
UBE2V1-005
UBE2V1-201
UBE2V1-202
UBE2V1-203
UBE2V1-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2V1-001
ENSP00000407770
ENST00000415862
Q13404 [Direct mapping]
Ubiquitin-conjugating enzyme E2 variant 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006282 [regulation of DNA repair]
GO:0006301 [postreplication repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0031371 [ubiquitin conjugating enzyme complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035370 [UBC13-UEV1A complex]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070534 [protein K63-linked ubiquitination]
Show all
 103 aa
11.8 kDa 		No 0
UBE2V1-002
ENSP00000360742
ENST00000371677
Q13404 [Direct mapping]
Ubiquitin-conjugating enzyme E2 variant 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006282 [regulation of DNA repair]
GO:0006301 [postreplication repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0031371 [ubiquitin conjugating enzyme complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035370 [UBC13-UEV1A complex]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070534 [protein K63-linked ubiquitination]
Show all
 170 aa
19.3 kDa 		No 0
UBE2V1-003
ENSP00000340305
ENST00000340309
Q13404 [Direct mapping]
Ubiquitin-conjugating enzyme E2 variant 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006282 [regulation of DNA repair]
GO:0006301 [postreplication repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0031371 [ubiquitin conjugating enzyme complex]
GO:0031624 [ubiquitin conjugating enzyme binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035370 [UBC13-UEV1A complex]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042275 [error-free postreplication DNA repair]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070534 [protein K63-linked ubiquitination]
Show all
 170 aa
19.3 kDa 		No 0
UBE2V1-004
ENSP00000360739
ENST00000371674
Q13404 [Direct mapping]
Ubiquitin-conjugating enzyme E2 variant 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006282 [regulation of DNA repair]
GO:0006301 [postreplication repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0031371 [ubiquitin conjugating enzyme complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035370 [UBC13-UEV1A complex]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070534 [protein K63-linked ubiquitination]
Show all
 147 aa
16.5 kDa 		No 0
UBE2V1-005
ENSP00000360720
ENST00000371657
Q13404 [Direct mapping]
Ubiquitin-conjugating enzyme E2 variant 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006282 [regulation of DNA repair]
GO:0006301 [postreplication repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0030154 [cell differentiation]
GO:0031371 [ubiquitin conjugating enzyme complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035370 [UBC13-UEV1A complex]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070062 [extracellular exosome]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070534 [protein K63-linked ubiquitination]
Show all
 105 aa
11.8 kDa 		No 0
UBE2V1-201
ENSP00000395264
ENST00000420027
A0A0A0MSL3 [Direct mapping]
Ubiquitin-conjugating enzyme E2 variant 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006301 [postreplication repair]
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 103 aa
11.8 kDa 		No 0
UBE2V1-202
ENSP00000450635
ENST00000557021
G3V2F7 [Direct mapping]
Ubiquitin-conjugating enzyme E2 variant 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006301 [postreplication repair]
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 105 aa
12 kDa 		No 0
UBE2V1-203
ENSP00000484828
ENST00000617119
G3V2F7 [Direct mapping]
Ubiquitin-conjugating enzyme E2 variant 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006301 [postreplication repair]
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 105 aa
12 kDa 		No 0
UBE2V1-204
ENSP00000485599
ENST00000625172
G3V2F7 [Direct mapping]
Ubiquitin-conjugating enzyme E2 variant 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006301 [postreplication repair]
GO:0016567 [protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 105 aa
12 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.