Expression of PTCHD4 in cancer - Summary - The Human Protein Atlas

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PTCHD4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PTCHD4
Gene description	Patched domain containing 4
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (melanoma, renal cancer, thyroid cancer)
HPA (cell line):	Cell line enhanced (AF22, BEWO, Hep G2, LHCN-M2, TIME, WM-115)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA041276
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (melanoma, renal cancer, thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041276

GENE INFORMATION
Gene name	PTCHD4 (HGNC Symbol)
Synonyms	C6orf138, dJ402H5.2, FLJ41841
Description	Patched domain containing 4 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p12.3
Chromosome location (bp)	47878028 - 48068689
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000244694 (version 83.38)
Entrez gene	442213
UniProt	Q6ZW05 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZW05
Antibodypedia	PTCHD4 antibodies

PROTEIN BROWSER

PTCHD4-001	PTCHD4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTCHD4-001 ENSP00000381722 ENST00000398738	H0Y3Q6 [Direct mapping] Patched domain-containing protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0007165 [signal transduction] GO:0008158 [hedgehog receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	311 aa 34.7 kDa	No	3
PTCHD4-002 ENSP00000341914 ENST00000339488	Q6ZW05 [Direct mapping] Patched domain-containing protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0007165 [signal transduction] GO:0008150 [biological_process] GO:0008158 [hedgehog receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	846 aa 96.4 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.