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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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HBB
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

HBB

Gene description

Hemoglobin, beta

Protein class

Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HEL, SCLC-21H, SH-SY5Y, U-266/70)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in erythrocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images. Tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 2 antibodies.
HPA043234 , CAB009526
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA043234
CAB009526

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular carcinomas along with occasional cases of renal cancers showed moderate to strong cytoplasmic positivity in a granular pattern. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Fractions of testicular and renal cancers among other showed distinct positivity. Cancer cells in general were negative.

GENE INFORMATION

Gene name

HBB (HGNC Symbol)

Synonyms

beta-globin, CD113t-C, HBD

Description

Hemoglobin, beta (HGNC Symbol)

Entrez gene summary

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

5225464 - 5229395

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000244734 (version 83.38)

Entrez gene

3043

UniProt

P68871 (UniProt - Evidence at protein level)

neXtProt

NX_P68871

Antibodypedia

HBB antibodies

PROTEIN BROWSER

HBB-001
HBB-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HBB-001
ENSP00000333994
ENST00000335295
P68871 [Direct mapping]
Hemoglobin subunit beta LVV-hemorphin-7 Spinorphin
D9YZU5 [Target identity:100%; Query identity:100%]
Hemoglobin, beta
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004601 [peroxidase activity]
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005833 [hemoglobin complex]
GO:0006898 [receptor-mediated endocytosis]
GO:0007596 [blood coagulation]
GO:0008217 [regulation of blood pressure]
GO:0010942 [positive regulation of cell death]
GO:0015671 [oxygen transport]
GO:0015701 [bicarbonate transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
GO:0030185 [nitric oxide transport]
GO:0030492 [hemoglobin binding]
GO:0031720 [haptoglobin binding]
GO:0031838 [haptoglobin-hemoglobin complex]
GO:0042542 [response to hydrogen peroxide]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0050880 [regulation of blood vessel size]
GO:0051291 [protein heterooligomerization]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070293 [renal absorption]
GO:0070527 [platelet aggregation]
GO:0071682 [endocytic vesicle lumen]
GO:0072562 [blood microparticle]
Show all
147 aa
16 kDa
No 0
HBB-004
ENSP00000369671
ENST00000380315
F8W6P5 [Direct mapping]
Hemoglobin subunit beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005344 [oxygen transporter activity]
GO:0005506 [iron ion binding]
GO:0005833 [hemoglobin complex]
GO:0015671 [oxygen transport]
GO:0019825 [oxygen binding]
GO:0020037 [heme binding]
Show all
90 aa
9.7 kDa
No 0

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