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Cell line enhanced (HEL, SCLC-21H, SH-SY5Y, U-266/70)
HPA (normal tissue):
Tissue enriched (bone marrow)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Expression in erythrocytes.
ANTIBODY IHC RELIABILITY
Data reliability description
Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images. Tissue location of RNA and protein might differ and correlation is complex.
Hepatocellular carcinomas along with occasional cases of renal cancers showed moderate to strong cytoplasmic positivity in a granular pattern. Remaining cancer tissues were negative.
Fractions of testicular and renal cancers among other showed distinct positivity. Cancer cells in general were negative.
GENE INFORMATION
Gene name
HBB (HGNC Symbol)
Synonyms
beta-globin, CD113t-C, HBD
Description
Hemoglobin, beta (HGNC Symbol)
Entrez gene summary
The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)