Expression of CRYBB2 in cancer - Summary - The Human Protein Atlas

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CRYBB2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CRYBB2
Gene description	Crystallin, beta B2
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in the lens.

ANTIBODY IHC RELIABILITY
Data reliability description	No internal RNA expression data available for correlation. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA043749
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043749

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Cancer tissues were negative.

GENE INFORMATION
Gene name	CRYBB2 (HGNC Symbol)
Synonyms	CCA2, CRYB2, CRYB2A
Description	Crystallin, beta B2 (HGNC Symbol)
Entrez gene summary	Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation was found to cause type 2 cerulean cataracts. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	25219522 - 25231869
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000244752 (version 83.38)
Entrez gene	1415
UniProt	P43320 (UniProt - Evidence at protein level)
neXtProt	NX_P43320
Antibodypedia	CRYBB2 antibodies

PROTEIN BROWSER

CRYBB2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRYBB2-001 ENSP00000381273 ENST00000398215	P43320 [Direct mapping] Beta-crystallin B2 R4UMM2 [Target identity:100%; Query identity:100%] Beta-crystallin B2 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005212 [structural constituent of eye lens] GO:0007601 [visual perception] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043010 [camera-type eye development] GO:0050896 [response to stimulus] Show all	205 aa 23.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.