Expression of CDK11B in cancer - Summary - The Human Protein Atlas

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CDK11B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CDK11B
Gene description	Cyclin-dependent kinase 11B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA025061
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA025061

GENE INFORMATION
Gene name	CDK11B (HGNC Symbol)
Synonyms	CDC2L1, CDK11-p110, CDK11-p46, CDK11-p58
Description	Cyclin-dependent kinase 11B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	1635227 - 1659012
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000248333 (version 83.38)
Entrez gene	984
UniProt
neXtProt
Antibodypedia	CDK11B antibodies

PROTEIN BROWSER

CDK11B-001	CDK11B-003	CDK11B-005	CDK11B-201	CDK11B-202	CDK11B-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDK11B-001 ENSP00000463048 ENST00000341832	B7ZVY7 [Direct mapping] Cell division cycle 2-like 1 (PITSLRE proteins); Cyclin-dependent kinase 11B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0051301 [cell division] Show all	782 aa 91.3 kDa	No	0
CDK11B-003 ENSP00000464036 ENST00000407249	J3QR44 [Direct mapping] Cyclin-dependent kinase 11B Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	795 aa 92.6 kDa	No	0
CDK11B-005 ENSP00000464016 ENST00000340677	J3QR29 [Direct mapping] Cyclin-dependent kinase 11B Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	748 aa 87.1 kDa	No	0
CDK11B-201 ENSP00000485705 ENST00000626918	A0A0D9SEI3 [Direct mapping] Cyclin-dependent kinase 11B Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	772 aa 89.4 kDa	No	0
CDK11B-202 ENSP00000485937 ENST00000629289	A0A0D9SER5 [Direct mapping] Cyclin-dependent kinase 11B Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	783 aa 90.2 kDa	No	0
CDK11B-203 ENSP00000485849 ENST00000629312	A0A0D9SEN2 [Direct mapping] Cyclin-dependent kinase 11B Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	785 aa 90.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.