Expression of ABHD14A in cancer - Summary - The Human Protein Atlas

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ABHD14A

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABHD14A
Gene description	Abhydrolase domain containing 14A
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA038154
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038154

GENE INFORMATION
Gene name	ABHD14A (HGNC Symbol)
Synonyms	DKFZP564O243, DORZ1
Description	Abhydrolase domain containing 14A (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p21.2
Chromosome location (bp)	51971426 - 51981199
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000248487 (version 83.38)
Entrez gene	25864
UniProt	Q9BUJ0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BUJ0
Antibodypedia	ABHD14A antibodies

PROTEIN BROWSER

ABHD14A-001	ABHD14A-005	ABHD14A-006	ABHD14A-008	ABHD14A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABHD14A-001 ENSP00000273596 ENST00000273596	Q9BUJ0 [Direct mapping] Alpha/beta hydrolase domain-containing protein 14A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	271 aa 29.8 kDa	No	0
ABHD14A-005 ENSP00000418242 ENST00000497864	C9J7W8 [Direct mapping] Alpha/beta hydrolase domain-containing protein 14A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	225 aa 24.1 kDa	No	1
ABHD14A-006 ENSP00000420475 ENST00000494478	C9JMW6 [Direct mapping] Alpha/beta hydrolase domain-containing protein 14A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	153 aa 16.4 kDa	No	0
ABHD14A-008 ENSP00000418824 ENST00000491470	C9IYJ8 [Direct mapping] Alpha/beta hydrolase domain-containing protein 14A Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 13.3 kDa	Yes	0
ABHD14A-201 ENSP00000390557 ENST00000458031	K7N7A0 [Direct mapping] Alpha/beta hydrolase domain-containing protein 14A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		229 aa 25.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.