Expression of SPATS1 in cancer - Summary - The Human Protein Atlas

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SPATS1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPATS1
Gene description	Spermatogenesis associated, serine-rich 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enriched (SK-MEL-30)
HPA (normal tissue):	Group enriched (fallopian tube, testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Expression in testis and fallopian tube.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA046230 , HPA049722
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA046230	HPA049722

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	A few cases of gliomas, melanomas, gastric and pancreatic cancers along with isolated cases of breast and ovarian cancers displayed moderate to strong cytoplasmic and nuclear positivity. Remaining cancer tissues were negative.

GENE INFORMATION
Gene name	SPATS1 (HGNC Symbol)
Synonyms	FLJ25442, SPATA8, SRSP1
Description	Spermatogenesis associated, serine-rich 1 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	44342660 - 44377167
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000249481 (version 83.38)
Entrez gene	221409
UniProt	Q496A3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q496A3
Antibodypedia	SPATS1 antibodies

PROTEIN BROWSER

SPATS1-001	SPATS1-003	SPATS1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPATS1-001 ENSP00000424400 ENST00000288390	Q496A3 [Direct mapping] Spermatogenesis-associated serine-rich protein 1 Show all	Predicted intracellular proteins Show all		300 aa 33.7 kDa	No	0
SPATS1-003 ENSP00000423654 ENST00000515220	H0Y9A9 [Direct mapping] Spermatogenesis-associated serine-rich protein 1 Show all	Predicted intracellular proteins Show all		118 aa 12.5 kDa	No	0
SPATS1-201 ENSP00000437552 ENST00000323108	Q496A3 [Direct mapping] Spermatogenesis-associated serine-rich protein 1 Show all	Predicted intracellular proteins Show all		300 aa 33.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.