Tissue expression of TMEM158 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TMEM158
Gene description	Transmembrane protein 158 (gene/pseudogene)
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (endometrium, seminal vesicle)
GTEx:	Tissue enhanced (caudate, endometrium)
FANTOM5:	Tissue enhanced (caudate)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (endometrium, seminal vesicle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, endometrium)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION
Gene name	TMEM158 (HGNC Symbol)
Synonyms	p40BBp, RIS1
Description	Transmembrane protein 158 (gene/pseudogene) (HGNC Symbol)
Entrez gene summary	Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	45224466 - 45226278
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000249992 (version 83.38)
Entrez gene	25907
UniProt	Q8WZ71 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WZ71
Antibodypedia	TMEM158 antibodies

PROTEIN BROWSER

TMEM158-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM158-001 ENSP00000422431 ENST00000503771	Q8WZ71 [Direct mapping] Transmembrane protein 158 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0042277 [peptide binding] Show all	300 aa 30.4 kDa	Yes	1