Expression of GPR162 in cancer - Summary - The Human Protein Atlas

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GPR162

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPR162
Gene description	G protein-coupled receptor 162
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enhanced (AF22, AN3-CA, NTERA-2, SH-SY5Y, U-2 OS)
HPA (normal tissue):	Group enriched (cerebral cortex, fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression with vesicle localization in neurons.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA055135
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055135

GENE INFORMATION
Gene name	GPR162 (HGNC Symbol)
Synonyms	A-2, GRCA
Description	G protein-coupled receptor 162 (HGNC Symbol)
Entrez gene summary	This gene was identified upon genomic analysis of a gene-dense region at human chromosome 12p13. It appears to be mainly expressed in the brain; however, its function is not known. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6821545 - 6829972
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000250510 (version 83.38)
Entrez gene	27239
UniProt	Q16538 (UniProt - Evidence at transcript level)
neXtProt	NX_Q16538
Antibodypedia	GPR162 antibodies

PROTEIN BROWSER

GPR162-001	GPR162-003	GPR162-004	GPR162-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPR162-001 ENSP00000399670 ENST00000428545	Q16538 [Direct mapping] Probable G-protein coupled receptor 162 Show all	G-protein coupled receptors GPCRs excl olfactory receptors MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	304 aa 33.1 kDa	No	0
GPR162-003 ENSP00000311528 ENST00000311268	Q16538 [Direct mapping] Probable G-protein coupled receptor 162 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	588 aa 63.9 kDa	No	7
GPR162-004 ENSP00000371752 ENST00000382315	J3KPJ9 [Direct mapping] G protein-coupled receptor 162, isoform CRA_b; Probable G-protein-coupled receptor 162 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	284 aa 30.9 kDa	Yes	0
GPR162-008 ENSP00000475912 ENST00000545321	U3KQI6 [Direct mapping] Probable G-protein-coupled receptor 162 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	228 aa 25.1 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.