Cell atlas - PRODH2 - The Human Protein Atlas

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PRODH2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PRODH2
Gene description	Proline dehydrogenase (oxidase) 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Cell line enriched (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA051287
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051287	Hep G2	Nucleoplasm
	HPA051287	Hep G2	Cytosol

GENE INFORMATION
Gene name	PRODH2 (HGNC Symbol)
Synonyms	HSPOX1
Description	Proline dehydrogenase (oxidase) 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is similar to proline dehydrogenase (oxidase) 1, a mitochondrial enzyme which catalyzes the first step in proline catabolism. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35799988 - 35813299
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000250799 (version 83.38)
Entrez gene	58510
UniProt	Q9UF12 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UF12
Antibodypedia	PRODH2 antibodies

PROTEIN BROWSER

PRODH2-001	PRODH2-006	PRODH2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRODH2-001 ENSP00000301175 ENST00000301175	Q9UF12 [Direct mapping] Probable proline dehydrogenase 2 Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0010133 [proline catabolic process to glutamate] GO:0055114 [oxidation-reduction process] Show all	536 aa 58.9 kDa	No	0
PRODH2-006 ENSP00000474199 ENST00000589835	S4R3D8 [Direct mapping] Probable proline dehydrogenase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0006562 [proline catabolic process] GO:0055114 [oxidation-reduction process] Show all	73 aa 8.1 kDa	No	0
PRODH2-007 ENSP00000465214 ENST00000588266	K7EJK5 [Direct mapping] Probable proline dehydrogenase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0006562 [proline catabolic process] GO:0055114 [oxidation-reduction process] Show all	119 aa 13.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.