Expression of ALG1L2 in cancer - Summary - The Human Protein Atlas

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ALG1L2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ALG1L2
Gene description	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (epididymis, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA060392
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable).
Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA060392

GENE INFORMATION
Gene name	ALG1L2
Synonyms
Description	ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q22.1
Chromosome location (bp)	130081831 - 130113227
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000251287 (version 83.38)
Entrez gene	644974
UniProt	C9J202 (UniProt - Inferred from homology)
neXtProt	NX_C9J202
Antibodypedia	ALG1L2 antibodies

PROTEIN BROWSER

ALG1L2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALG1L2-003 ENSP00000479850 ENST00000425059	C9J202 [Direct mapping] Putative glycosyltransferase ALG1L2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0008152 [metabolic process] GO:0016757 [transferase activity, transferring glycosyl groups] Show all	215 aa 24.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.