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Tumor cells showed strong nuclear immunoreactivity, accompanied with weak cytoplasmic staining in some cases e.g. prostate cancers. Several renal carcinomas were negative.
GENE INFORMATION
Gene name
PRKDC (HGNC Symbol)
Synonyms
DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, p350, XRCC7
Description
Protein kinase, DNA-activated, catalytic polypeptide (HGNC Symbol)
Entrez gene summary
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]