Expression of UTP14C in cancer - Summary - The Human Protein Atlas

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UTP14C

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UTP14C
Gene description	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 2 antibodies. HPA047217 , HPA054023
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047217	HPA054023

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most cancer cells displayed moderate to strong cytoplasmic positivity. Additional membranous staining was observed in several ovarian cancers. Lymphomas, lung, urothelial, renal, pancreatic and liver cancers were negative.

GENE INFORMATION
Gene name	UTP14C (HGNC Symbol)
Synonyms	2700066J21Rik, KIAA0266
Description	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q14.3
Chromosome location (bp)	52024691 - 52033600
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000253797 (version 83.38)
Entrez gene	9724
UniProt	Q5TAP6 (UniProt - Evidence at protein level)
neXtProt	NX_Q5TAP6
Antibodypedia	UTP14C antibodies

PROTEIN BROWSER

UTP14C-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UTP14C-001 ENSP00000428619 ENST00000521776	Q5TAP6 [Direct mapping] U3 small nucleolar RNA-associated protein 14 homolog C A0A024RDV0 [Target identity:100%; Query identity:100%] HCG1811699, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0032040 [small-subunit processome] GO:0051321 [meiotic cell cycle] Show all	766 aa 87.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.