Expression of AP5B1 in cancer - Summary - The Human Protein Atlas

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AP5B1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AP5B1
Gene description	Adaptor-related protein complex 5, beta 1 subunit
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and membranous expression, most abundant in glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA065739 , HPA067880
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA065739	HPA067880

GENE INFORMATION
Gene name	AP5B1 (HGNC Symbol)
Synonyms	AP-5, DKFZp761E198, PP1030
Description	Adaptor-related protein complex 5, beta 1 subunit (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65775893 - 65780802
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000254470 (version 83.38)
Entrez gene	91056
UniProt	Q2VPB7 (UniProt - Evidence at protein level)
neXtProt	NX_Q2VPB7
Antibodypedia	AP5B1 antibodies

PROTEIN BROWSER

AP5B1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AP5B1-001 ENSP00000454303 ENST00000532090	Q2VPB7 [Direct mapping] AP-5 complex subunit beta-1 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0015031 [protein transport] GO:0016197 [endosomal transport] GO:0030119 [AP-type membrane coat adaptor complex] Show all	878 aa 93.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.