Expression of ANKHD1-EIF4EBP3 in cancer - Summary - The Human Protein Atlas

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ANKHD1-EIF4EBP3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANKHD1-EIF4EBP3
Gene description	ANKHD1-EIF4EBP3 readthrough
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA008718
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008718

GENE INFORMATION
Gene name	ANKHD1-EIF4EBP3 (HGNC Symbol)
Synonyms	MASK-BP3
Description	ANKHD1-EIF4EBP3 readthrough (HGNC Symbol)
Entrez gene summary	The ANKHD1-EIF4EBP3 mRNA is an infrequent but naturally occurring readthrough transcript of the neighboring ANKHD1 and EIF4EBP3 genes. This readthrough transcript encodes a protein composed mostly of the multiple ankyrin repeats, single KH-domain protein, with its C-terminus encoded in a different reading frame from the shared portion of the EIF4EBP3 gene. The significance of this readthrough mRNA and the function of its protein product have not yet been determined. [provided by RefSeq, Nov 2009]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	140401908 - 140549569
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000254996 (version 83.38)
Entrez gene	404734
UniProt
neXtProt
Antibodypedia	ANKHD1-EIF4EBP3 antibodies

PROTEIN BROWSER

ANKHD1-EIF4EBP3-001	ANKHD1-EIF4EBP3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKHD1-EIF4EBP3-001 ENSP00000432016 ENST00000532219		Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] Show all	2617 aa 277.2 kDa	No	0
ANKHD1-EIF4EBP3-002 ENSP00000396882 ENST00000437495	H7C0V5 [Direct mapping] Protein ANKHD1-EIF4EBP3 Show all	Predicted intracellular proteins Show all		636 aa 66.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.