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CHMP1B

GENERAL INFORMATION

Gene name

 CHMP1B

Gene description

 Charged multivesicular body protein 1B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA061997 , HPA062896
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA061997
HPA062896

GENE INFORMATION

Gene name

 CHMP1B (HGNC Symbol)

Synonyms

 C18orf2, CHMP1.5, Vps46B

Description

 Charged multivesicular body protein 1B (HGNC Symbol)

Entrez gene summary

 CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Chromosome

 18

Cytoband

 p11.21

Chromosome location (bp)

 11851396 - 11854449

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000255112 (version 83.38)

Entrez gene

 57132

UniProt

 Q7LBR1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7LBR1

Antibodypedia

 CHMP1B antibodies

PROTEIN BROWSER
CHMP1B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHMP1B-001
ENSP00000432279
ENST00000526991
Q7LBR1 [Direct mapping]
Charged multivesicular body protein 1b
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000815 [ESCRT III complex]
GO:0000920 [cell separation after cytokinesis]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0010824 [regulation of centrosome duplication]
GO:0015031 [protein transport]
GO:0019904 [protein domain specific binding]
GO:0030117 [membrane coat]
GO:0031902 [late endosome membrane]
GO:0039702 [viral budding via host ESCRT complex]
GO:0045184 [establishment of protein localization]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:1901673 [regulation of mitotic spindle assembly]
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 199 aa
22.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.