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FXYD6-FXYD2

GENERAL INFORMATION

Gene name

 FXYD6-FXYD2

Gene description

 FXYD6-FXYD2 readthrough

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (kidney)
FANTOM5:Expressed in all

Protein evidence

 Evidence at transcript level

Protein expression

 Membranous expression in renal tubules, bile duct cells, glandular cells in salivary gland, gallbladder and exocrine pancreas.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA068838
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FXYD6-FXYD2

Synonyms

Description

 FXYD6-FXYD2 readthrough (HGNC Symbol)

Entrez gene summary

 This locus represents naturally occurring read-through transcription between the neighboring FXYD domain-containing ion transport regulator 6 (GeneID 53826) and sodium/potassium-transporting ATPase subunit gamma (GeneID 486) genes on chromosome 11. One read-through transcript produces a fusion protein that shares sequence identity with each individual gene product, while another read-through transcript encodes a protein that has a distinct C-terminus and only shares sequence identity with the upstream locus (GeneID 53826). [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 117820163 - 117876667

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000255245 (version 83.38)

Entrez gene

 100533181

UniProt

neXtProt

Antibodypedia

 FXYD6-FXYD2 antibodies

PROTEIN BROWSER
FXYD6-FXYD2-001
FXYD6-FXYD2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FXYD6-FXYD2-001
ENSP00000463024
ENST00000532984
A0A0A6YYL5 [Direct mapping]
Protein FXYD6-FXYD2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 112 aa
12.8 kDa 		Yes 1
FXYD6-FXYD2-002
ENSP00000482442
ENST00000614497
A0A087WZ82 [Direct mapping]
FXYD domain-containing ion transport regulator 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0017080 [sodium channel regulator activity]
GO:0034220 [ion transmembrane transport]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 144 aa
16.3 kDa 		Yes 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.