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NOX5

GENERAL INFORMATION

Gene name

 NOX5

Gene description

 NADPH oxidase, EF-hand calcium binding domain 5

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enhanced (spleen)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 NOX5 (HGNC Symbol)

Synonyms

 NOX5A, NOX5B

Description

 NADPH oxidase, EF-hand calcium binding domain 5 (HGNC Symbol)

Entrez gene summary

 This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 15

Cytoband

 q23

Chromosome location (bp)

 68930525 - 69062743

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000255346 (version 83.38)

Entrez gene

 79400

UniProt

 Q96PH1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96PH1

Antibodypedia

 NOX5 antibodies

PROTEIN BROWSER
NOX5-003
NOX5-004
NOX5-010
NOX5-011
NOX5-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOX5-003
ENSP00000373518
ENST00000388866
Q96PH1 [Direct mapping]
NADPH oxidase 5
Show all
Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Show all
GO:0000910 [cytokinesis]
GO:0001525 [angiogenesis]
GO:0001935 [endothelial cell proliferation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0006915 [apoptotic process]
GO:0008283 [cell proliferation]
GO:0010155 [regulation of proton transport]
GO:0015252 [hydrogen ion channel activity]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016175 [superoxide-generating NADPH oxidase activity]
GO:0016491 [oxidoreductase activity]
GO:0020037 [heme binding]
GO:0042554 [superoxide anion generation]
GO:0043012 [regulation of fusion of sperm to egg plasma membrane]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0050663 [cytokine secretion]
GO:0055114 [oxidation-reduction process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 765 aa
86.4 kDa 		No 8
NOX5-004
ENSP00000432440
ENST00000530406
Q96PH1 [Direct mapping]
NADPH oxidase 5
Show all
Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Show all
GO:0000910 [cytokinesis]
GO:0001525 [angiogenesis]
GO:0001935 [endothelial cell proliferation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0006915 [apoptotic process]
GO:0008283 [cell proliferation]
GO:0010155 [regulation of proton transport]
GO:0015252 [hydrogen ion channel activity]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016175 [superoxide-generating NADPH oxidase activity]
GO:0016491 [oxidoreductase activity]
GO:0020037 [heme binding]
GO:0042554 [superoxide anion generation]
GO:0043012 [regulation of fusion of sperm to egg plasma membrane]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0050663 [cytokine secretion]
GO:0055114 [oxidation-reduction process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 737 aa
83.8 kDa 		No 8
NOX5-010
ENSP00000454143
ENST00000260364
Q96PH1 [Direct mapping]
NADPH oxidase 5
Show all
Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Show all
GO:0000910 [cytokinesis]
GO:0001525 [angiogenesis]
GO:0001935 [endothelial cell proliferation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0006915 [apoptotic process]
GO:0008283 [cell proliferation]
GO:0010155 [regulation of proton transport]
GO:0015252 [hydrogen ion channel activity]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016175 [superoxide-generating NADPH oxidase activity]
GO:0016491 [oxidoreductase activity]
GO:0020037 [heme binding]
GO:0042554 [superoxide anion generation]
GO:0043012 [regulation of fusion of sperm to egg plasma membrane]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0050663 [cytokine secretion]
GO:0055114 [oxidation-reduction process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 747 aa
84.7 kDa 		No 8
NOX5-011
ENSP00000410887
ENST00000448182
Q96PH1 [Direct mapping]
NADPH oxidase 5
Show all
Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Show all
GO:0000910 [cytokinesis]
GO:0001525 [angiogenesis]
GO:0001935 [endothelial cell proliferation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0006915 [apoptotic process]
GO:0008283 [cell proliferation]
GO:0010155 [regulation of proton transport]
GO:0015252 [hydrogen ion channel activity]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016175 [superoxide-generating NADPH oxidase activity]
GO:0016491 [oxidoreductase activity]
GO:0020037 [heme binding]
GO:0042554 [superoxide anion generation]
GO:0043012 [regulation of fusion of sperm to egg plasma membrane]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0050663 [cytokine secretion]
GO:0055114 [oxidation-reduction process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 719 aa
82 kDa 		No 8
NOX5-012
ENSP00000416828
ENST00000455873
Q96PH1 [Direct mapping]
NADPH oxidase 5
Show all
Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Show all
GO:0000910 [cytokinesis]
GO:0001525 [angiogenesis]
GO:0001935 [endothelial cell proliferation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0006915 [apoptotic process]
GO:0008283 [cell proliferation]
GO:0010155 [regulation of proton transport]
GO:0015252 [hydrogen ion channel activity]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016175 [superoxide-generating NADPH oxidase activity]
GO:0016491 [oxidoreductase activity]
GO:0020037 [heme binding]
GO:0042554 [superoxide anion generation]
GO:0043012 [regulation of fusion of sperm to egg plasma membrane]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0050661 [NADP binding]
GO:0050663 [cytokine secretion]
GO:0055114 [oxidation-reduction process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 730 aa
83.1 kDa 		No 8

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.