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CTSO

GENERAL INFORMATION

Gene name

 CTSO

Gene description

 Cathepsin O

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Karpas-707)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA002041
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002041

GENE INFORMATION

Gene name

 CTSO (HGNC Symbol)

Synonyms

 CTSO1

Description

 Cathepsin O (HGNC Symbol)

Entrez gene summary

 The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q32.1

Chromosome location (bp)

 155924118 - 155953917

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000256043 (version 83.38)

Entrez gene

 1519

UniProt

 P43234 (UniProt - Evidence at transcript level)

neXtProt

 NX_P43234

Antibodypedia

 CTSO antibodies

PROTEIN BROWSER
CTSO-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTSO-001
ENSP00000414904
ENST00000433477
P43234 [Direct mapping]
Cathepsin O
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004197 [cysteine-type endopeptidase activity]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
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 321 aa
36 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.