Expression of APOPT1 in cancer - Summary - The Human Protein Atlas

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APOPT1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	APOPT1
Gene description	Apoptogenic 1, mitochondrial
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and ovarian cancer (favourable).
Liver cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	APOPT1 (HGNC Symbol)
Synonyms	APOP-1, C14orf153, MGC2562
Description	Apoptogenic 1, mitochondrial (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that localizes to the mitochondria, where it stimulates the release of cytochrome c, thereby promoting programmed cell death. Mutations in this gene have been found in individuals with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Chromosome	14
Cytoband	q32.33
Chromosome location (bp)	103562962 - 103607523
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000256053 (version 83.38)
Entrez gene	84334
UniProt	Q96IL0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96IL0
Antibodypedia	APOPT1 antibodies

PROTEIN BROWSER

APOPT1-001	APOPT1-004	APOPT1-005	APOPT1-006	APOPT1-008	APOPT1-009	APOPT1-010	APOPT1-014	APOPT1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOPT1-001 ENSP00000386485 ENST00000409074	Q96IL0 [Direct mapping] Apoptogenic protein 1, mitochondrial Show all	Predicted intracellular proteins Show all	GO:0005739 [mitochondrion] GO:0034393 [positive regulation of smooth muscle cell apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0097193 [intrinsic apoptotic signaling pathway] Show all	206 aa 24.2 kDa	No	0
APOPT1-004 ENSP00000451703 ENST00000495778	H0YJK3 [Direct mapping] Apoptogenic protein 1, mitochondrial Show all	Predicted intracellular proteins Show all		108 aa 12.6 kDa	No	0
APOPT1-005 ENSP00000388067 ENST00000440963	H7BZ67 [Direct mapping] Apoptogenic protein 1, mitochondrial Show all	Predicted intracellular proteins Show all		118 aa 13.6 kDa	No	0
APOPT1-006 ENSP00000489557 ENST00000492189		Phobius predicted membrane proteins Predicted intracellular proteins Show all		55 aa 7 kDa	No	0
APOPT1-008 ENSP00000489152 ENST00000477116		Phobius predicted membrane proteins Predicted intracellular proteins Show all		55 aa 7 kDa	No	0
APOPT1-009 ENSP00000489380 ENST00000473127		Phobius predicted membrane proteins Predicted intracellular proteins Show all		55 aa 7 kDa	No	0
APOPT1-010 ENSP00000489047 ENST00000476323		Predicted intracellular proteins Show all		76 aa 8.9 kDa	No	0
APOPT1-014 ENSP00000489308 ENST00000554876		Predicted intracellular proteins Show all		132 aa 15.4 kDa	No	0
APOPT1-015 ENSP00000451874 ENST00000556253	G3V4L6 [Direct mapping] Apoptogenic protein 1, mitochondrial Show all	Predicted intracellular proteins Show all		177 aa 20.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.