Expression of SMLR1 in cancer - Summary - The Human Protein Atlas

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SMLR1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SMLR1
Gene description	Small leucine-rich protein 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Group enriched (duodenum, liver, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA066060
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA066060

GENE INFORMATION
Gene name	SMLR1
Synonyms
Description	Small leucine-rich protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	q23.1
Chromosome location (bp)	130827406 - 130837135
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000256162 (version 83.38)
Entrez gene	100507203
UniProt	H3BR10 (UniProt - Evidence at protein level)
neXtProt	NX_H3BR10
Antibodypedia	SMLR1 antibodies

PROTEIN BROWSER

SMLR1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMLR1-001 ENSP00000456026 ENST00000541421	H3BR10 [Direct mapping] Small leucine-rich protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	107 aa 12.3 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.