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POLG2

GENERAL INFORMATION

Gene name

 POLG2

Gene description

 Polymerase (DNA directed), gamma 2, accessory subunit

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA023202 , CAB017030
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and prostate cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Prostate cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA023202
CAB017030

GENE INFORMATION

Gene name

 POLG2 (HGNC Symbol)

Synonyms

 HP55, MTPOLB

Description

 Polymerase (DNA directed), gamma 2, accessory subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 q23.3

Chromosome location (bp)

 64477785 - 64497036

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000256525 (version 83.38)

Entrez gene

 11232

UniProt

 Q9UHN1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHN1

Antibodypedia

 POLG2 antibodies

PROTEIN BROWSER
POLG2-001
POLG2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLG2-001
ENSP00000442563
ENST00000539111
Q9UHN1 [Direct mapping]
DNA polymerase subunit gamma-2, mitochondrial
E5KS15 [Target identity:100%; Query identity:100%]
Mitochondrial DNA polymerase subunit gamma-2; Polymerase (DNA directed), gamma 2, accessory subunit
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000262 [mitochondrial chromosome]
GO:0001701 [in utero embryonic development]
GO:0003677 [DNA binding]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006260 [DNA replication]
GO:0006261 [DNA-dependent DNA replication]
GO:0006264 [mitochondrial DNA replication]
GO:0006281 [DNA repair]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0022904 [respiratory electron transport chain]
GO:0032042 [mitochondrial DNA metabolic process]
GO:0042645 [mitochondrial nucleoid]
GO:0042802 [identical protein binding]
GO:0070062 [extracellular exosome]
GO:0070584 [mitochondrion morphogenesis]
GO:0071897 [DNA biosynthetic process]
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 485 aa
54.9 kDa 		No 0
POLG2-006
ENSP00000462071
ENST00000581355
J3KRM2 [Direct mapping]
DNA polymerase subunit gamma-2, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005739 [mitochondrion]
GO:0006264 [mitochondrial DNA replication]
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 151 aa
17.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.