Expression of PGA5 in cancer - Summary - The Human Protein Atlas

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PGA5

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PGA5
Gene description	Pepsinogen 5, group I (pepsinogen A)
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (stomach cancer)
HPA (cell line):	Cell line enriched (BJ hTERT+)
HPA (normal tissue):	Tissue enriched (stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in stomach.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA046875
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046875

GENE INFORMATION
Gene name	PGA5
Synonyms
Description	Pepsinogen 5, group I (pepsinogen A) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	61241042 - 61251448
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000256713 (version 83.38)
Entrez gene	5222
UniProt	P0DJD9 (UniProt - Evidence at protein level)
neXtProt	NX_P0DJD9
Antibodypedia	PGA5 antibodies

PROTEIN BROWSER

PGA5-001	PGA5-005	PGA5-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PGA5-001 ENSP00000309542 ENST00000312403	P0DJD9 [Direct mapping] Pepsin A-5 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0007586 [digestion] GO:0030163 [protein catabolic process] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] GO:0097486 [multivesicular body lumen] Show all	388 aa 42 kDa	Yes	0
PGA5-005 ENSP00000441981 ENST00000541528	F5GWT0 [Direct mapping] Pepsin A-5 Show all	Predicted intracellular proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	128 aa 13.3 kDa	No	0
PGA5-006 ENSP00000408739 ENST00000451616	C9JM59 [Direct mapping] Pepsin A-5 Show all	Predicted intracellular proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	234 aa 24.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.