Expression of HP in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HP
Gene description	Haptoglobin
Protein class	Cancer-related genes Candidate cardiovascular disease genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective granular cytoplasmic expression in liver with distinct positivity in plasma and extracellular matrix.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA047750 , CAB003787
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA047750	CAB003787

GENE INFORMATION
Gene name	HP
Synonyms
Description	Haptoglobin (HGNC Symbol)
Entrez gene summary	This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Chromosome	16
Cytoband	q22.2
Chromosome location (bp)	72054592 - 72061055
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000257017 (version 83.38)
Entrez gene	3240
UniProt	P00738 (UniProt - Evidence at protein level)
neXtProt	NX_P00738
Antibodypedia	HP antibodies

PROTEIN BROWSER

HP-001	HP-002	HP-003	HP-009	HP-011	HP-012	HP-014	HP-015	HP-016	HP-018	HP-019	HP-201	HP-202	HP-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HP-001 ENSP00000457629 ENST00000570083	P00738 [Direct mapping] Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0002376 [immune system process] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006952 [defense response] GO:0006953 [acute-phase response] GO:0010942 [positive regulation of cell death] GO:0016209 [antioxidant activity] GO:0030492 [hemoglobin binding] GO:0031838 [haptoglobin-hemoglobin complex] GO:0042542 [response to hydrogen peroxide] GO:0042742 [defense response to bacterium] GO:0051354 [negative regulation of oxidoreductase activity] GO:0070062 [extracellular exosome] GO:0071682 [endocytic vesicle lumen] GO:0072562 [blood microparticle] GO:2000296 [negative regulation of hydrogen peroxide catabolic process] Show all	347 aa 38.5 kDa	Yes	0
HP-002 ENSP00000348170 ENST00000355906	P00738 [Direct mapping] Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002376 [immune system process] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006952 [defense response] GO:0006953 [acute-phase response] GO:0010942 [positive regulation of cell death] GO:0016209 [antioxidant activity] GO:0030492 [hemoglobin binding] GO:0031838 [haptoglobin-hemoglobin complex] GO:0042542 [response to hydrogen peroxide] GO:0042742 [defense response to bacterium] GO:0051354 [negative regulation of oxidoreductase activity] GO:0070062 [extracellular exosome] GO:0071682 [endocytic vesicle lumen] GO:0072562 [blood microparticle] GO:2000296 [negative regulation of hydrogen peroxide catabolic process] Show all	406 aa 45.2 kDa	Yes	0
HP-003 ENSP00000454966 ENST00000565574	A0A0C4DGL8 [Direct mapping] Haptoglobin Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0030492 [hemoglobin binding] Show all	347 aa 38.5 kDa	Yes	0
HP-009 ENSP00000463491 ENST00000567612	J3QLC9 [Direct mapping] Haptoglobin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] GO:0030492 [hemoglobin binding] Show all	365 aa 40.7 kDa	Yes	0
HP-011 ENSP00000463755 ENST00000569639	J3QQI8 [Direct mapping] Haptoglobin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 9.9 kDa	Yes	0
HP-012 ENSP00000350406 ENST00000357763	H0Y300 [Direct mapping] Haptoglobin Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	442 aa 49.1 kDa	Yes	0
HP-014 ENSP00000456503 ENST00000564499	H3BS21 [Direct mapping] Haptoglobin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	222 aa 24.8 kDa	Yes	0
HP-015 ENSP00000454413 ENST00000562526	H3BMJ7 [Direct mapping] Haptoglobin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 10.2 kDa	Yes	0
HP-016 ENSP00000464070 ENST00000567185	J3QR68 [Direct mapping] Haptoglobin Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	404 aa 44.9 kDa	Yes	0
HP-018 ENSP00000462662 ENST00000568417	J3KSV1 [Direct mapping] Haptoglobin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		88 aa 9.7 kDa	Yes	0
HP-019 ENSP00000461999 ENST00000576168	J3KRH2 [Direct mapping] Haptoglobin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 16.5 kDa	Yes	0
HP-201 ENSP00000228226 ENST00000228226	A0A087WU08 [Direct mapping] Haptoglobin Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	281 aa 31.4 kDa	No	0
HP-202 ENSP00000381199 ENST00000398131	P00738 [Direct mapping] Haptoglobin Haptoglobin alpha chain Haptoglobin beta chain Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002376 [immune system process] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006952 [defense response] GO:0006953 [acute-phase response] GO:0010942 [positive regulation of cell death] GO:0016209 [antioxidant activity] GO:0030492 [hemoglobin binding] GO:0031838 [haptoglobin-hemoglobin complex] GO:0042542 [response to hydrogen peroxide] GO:0042742 [defense response to bacterium] GO:0051354 [negative regulation of oxidoreductase activity] GO:0070062 [extracellular exosome] GO:0071682 [endocytic vesicle lumen] GO:0072562 [blood microparticle] GO:2000296 [negative regulation of hydrogen peroxide catabolic process] Show all	347 aa 38.5 kDa	Yes	0
HP-203 ENSP00000478279 ENST00000613898	A0A087WU08 [Direct mapping] Haptoglobin Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	281 aa 31.4 kDa	No	0