Expression of TAS2R38 in cancer - Summary - The Human Protein Atlas

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TAS2R38

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TAS2R38
Gene description	Taste receptor, type 2, member 38
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Mainly cytoplasmic and membranous expression in glandular tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	No RNA expression data detected and pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA043862 , HPA054366
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Urothelial cancer

STAINING SUMMARY

HPA043862	HPA054366

GENE INFORMATION
Gene name	TAS2R38 (HGNC Symbol)
Synonyms	PTC, T2R61
Description	Taste receptor, type 2, member 38 (HGNC Symbol)
Entrez gene summary	This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	141972631 - 141973773
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000257138 (version 83.38)
Entrez gene	5726
UniProt	P59533 (UniProt - Evidence at transcript level)
neXtProt	NX_P59533
Antibodypedia	TAS2R38 antibodies

PROTEIN BROWSER

TAS2R38-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TAS2R38-001 ENSP00000448219 ENST00000547270	P59533 [Direct mapping] Taste receptor type 2 member 38 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family T2R receptors (taste receptor GPCRs) Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001580 [detection of chemical stimulus involved in sensory perception of bitter taste] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0033038 [bitter taste receptor activity] GO:0050909 [sensory perception of taste] Show all	333 aa 37.9 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.