Tissue expression of MGAM - Summary - The Human Protein Atlas

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MGAM

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MGAM
Gene description	Maltase-glucoamylase
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (duodenum, small intestine)
GTEx:	Tissue enriched (small intestine)
FANTOM5:	Tissue enhanced (colon, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Distinct membranous expression in small intestine and kidney as well as cytoplasmic expression in subsets of leukocytes.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA002270
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Small intestine

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (duodenum, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon, small intestine)

GENE INFORMATION
Gene name	MGAM (HGNC Symbol)
Synonyms	MGA
Description	Maltase-glucoamylase (HGNC Symbol)
Entrez gene summary	This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	141907813 - 142106747
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000257335 (version 83.38)
Entrez gene	8972
UniProt	O43451 (UniProt - Evidence at protein level)
neXtProt	NX_O43451
Antibodypedia	MGAM antibodies

PROTEIN BROWSER

MGAM-001	MGAM-002	MGAM-007	MGAM-008	MGAM-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGAM-001 ENSP00000447378 ENST00000549489	O43451 [Direct mapping] Maltase-glucoamylase, intestinal Maltase Glucoamylase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000023 [maltose metabolic process] GO:0003824 [catalytic activity] GO:0004339 [glucan 1,4-alpha-glucosidase activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004558 [alpha-1,4-glucosidase activity] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0005983 [starch catabolic process] GO:0016021 [integral component of membrane] GO:0016160 [amylase activity] GO:0016324 [apical plasma membrane] GO:0030246 [carbohydrate binding] GO:0032450 [maltose alpha-glucosidase activity] GO:0044245 [polysaccharide digestion] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	1857 aa 209.9 kDa	No	1
MGAM-002 ENSP00000419372 ENST00000465654	E7EW87 [Direct mapping] Maltase-glucoamylase, intestinal Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	185 aa 19.8 kDa	No	1
MGAM-007 ENSP00000417515 ENST00000475668	E7ER45 [Direct mapping] Maltase-glucoamylase, intestinal Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0005975 [carbohydrate metabolic process] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	2753 aa 312 kDa	No	1
MGAM-008 ENSP00000417103 ENST00000497673	E9PEQ5 [Direct mapping] Maltase-glucoamylase, intestinal Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	143 aa 15.2 kDa	No	1
MGAM-201 ENSP00000482292 ENST00000620571	O43451 [Direct mapping] Maltase-glucoamylase, intestinal Maltase Glucoamylase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000023 [maltose metabolic process] GO:0003824 [catalytic activity] GO:0004339 [glucan 1,4-alpha-glucosidase activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004558 [alpha-1,4-glucosidase activity] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0005983 [starch catabolic process] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030246 [carbohydrate binding] GO:0032450 [maltose alpha-glucosidase activity] GO:0044245 [polysaccharide digestion] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	1857 aa 209.9 kDa	No	1

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The Human Protein Atlas

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