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BCL2L2-PABPN1

GENERAL INFORMATION

Gene name

 BCL2L2-PABPN1

Gene description

 BCL2L2-PABPN1 readthrough

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA000637
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000637

GENE INFORMATION

Gene name

 BCL2L2-PABPN1

Synonyms

Description

 BCL2L2-PABPN1 readthrough (HGNC Symbol)

Entrez gene summary

 This locus represents naturally occurring read-through transcription between the neighboring BCL2L2 (BCL2-like 2) and PABPN1 (poly(A) binding protein, nuclear 1) genes on chromosome 14. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 23306835 - 23325369

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000258643 (version 83.38)

Entrez gene

 100529063

UniProt

 Q92843 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92843

Antibodypedia

 BCL2L2-PABPN1 antibodies

PROTEIN BROWSER
BCL2L2-PABPN1-001
BCL2L2-PABPN1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCL2L2-PABPN1-001
ENSP00000451320
ENST00000553781
Q92843 [Direct mapping]
Bcl-2-like protein 2
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Transporters
   Transporter channels and pores
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
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GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005741 [mitochondrial outer membrane]
GO:0007283 [spermatogenesis]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
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 333 aa
37.2 kDa 		No 0
BCL2L2-PABPN1-002
ENSP00000452479
ENST00000557008
Q92843 [Direct mapping]
Bcl-2-like protein 2
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Transporters
   Transporter channels and pores
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005741 [mitochondrial outer membrane]
GO:0007283 [spermatogenesis]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
 333 aa
37.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.