Expression of RNASE4 in cancer - Summary - The Human Protein Atlas

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RNASE4

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	RNASE4
Gene description	Ribonuclease, RNase A family, 4
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (liver cancer)
HPA (cell line):	Cell line enhanced (ASC TERT1, Hep G2)
HPA (normal tissue):	Tissue enhanced (liver)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	RNASE4 (HGNC Symbol)
Synonyms	RAB1
Description	Ribonuclease, RNase A family, 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	20684100 - 20701215
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000258818 (version 83.38)
Entrez gene	6038
UniProt	P34096 (UniProt - Evidence at protein level)
neXtProt	NX_P34096
Antibodypedia	RNASE4 antibodies

PROTEIN BROWSER

RNASE4-002	RNASE4-003	RNASE4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNASE4-002 ENSP00000451624 ENST00000555597	P34096 [Direct mapping] Ribonuclease 4 Q53XB4 [Target identity:100%; Query identity:100%] Full-length cDNA clone CS0DF032YM23 of Fetal brain of Homo sapiens (human); Full-length cDNA clone CS0DM007YH13 of Fetal liver of Homo sapiens (human); HCG2044782, isoform CRA_a; Ribonuclease A B1; cDNA FLJ35103 fis, clone PLACE6006549, highly similar to RIBONUCLEASE 4 (EC 3.1.27.-) Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004519 [endonuclease activity] GO:0004522 [ribonuclease A activity] GO:0004540 [ribonuclease activity] GO:0005576 [extracellular region] GO:0006379 [mRNA cleavage] GO:0070062 [extracellular exosome] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	147 aa 16.8 kDa	Yes	0
RNASE4-003 ENSP00000381081 ENST00000397995	P34096 [Direct mapping] Ribonuclease 4 Q53XB4 [Target identity:100%; Query identity:100%] Full-length cDNA clone CS0DF032YM23 of Fetal brain of Homo sapiens (human); Full-length cDNA clone CS0DM007YH13 of Fetal liver of Homo sapiens (human); HCG2044782, isoform CRA_a; Ribonuclease A B1; cDNA FLJ35103 fis, clone PLACE6006549, highly similar to RIBONUCLEASE 4 (EC 3.1.27.-) Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Show all	GO:0003676 [nucleic acid binding] GO:0004519 [endonuclease activity] GO:0004522 [ribonuclease A activity] GO:0004540 [ribonuclease activity] GO:0005576 [extracellular region] GO:0006379 [mRNA cleavage] GO:0070062 [extracellular exosome] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	147 aa 16.8 kDa	Yes	0
RNASE4-004 ENSP00000452245 ENST00000555835	P34096 [Direct mapping] Ribonuclease 4 Q53XB4 [Target identity:100%; Query identity:100%] Full-length cDNA clone CS0DF032YM23 of Fetal brain of Homo sapiens (human); Full-length cDNA clone CS0DM007YH13 of Fetal liver of Homo sapiens (human); HCG2044782, isoform CRA_a; Ribonuclease A B1; cDNA FLJ35103 fis, clone PLACE6006549, highly similar to RIBONUCLEASE 4 (EC 3.1.27.-) Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004519 [endonuclease activity] GO:0004522 [ribonuclease A activity] GO:0004540 [ribonuclease activity] GO:0005576 [extracellular region] GO:0006379 [mRNA cleavage] GO:0070062 [extracellular exosome] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	147 aa 16.8 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.