Expression of ERCC6-PGBD3 in cancer - Summary - The Human Protein Atlas

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ERCC6-PGBD3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ERCC6-PGBD3
Gene description	ERCC6-PGBD3 readthrough
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA025825
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA025825

GENE INFORMATION
Gene name	ERCC6-PGBD3
Synonyms
Description	ERCC6-PGBD3 readthrough (HGNC Symbol)
Entrez gene summary	This locus represents naturally-occurring readthrough transcription between the neighboring ERCC6 (excision repair cross-complementing rodent repair deficiency, complementation group 6) and PGBD (piggyBac transposable element derived 3) genes on chromosome 10. The readthrough transcripts encode a fusion protein that shares sequence with the product of each individual gene. The encoded protein may function in DNA repair and in the innate immune response. It binds to MER85 sequences in DNA, and may interact with transcription factors to modulate gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Chromosome	10
Cytoband	q11.23
Chromosome location (bp)	49515201 - 49539538
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000258838 (version 83.38)
Entrez gene	101243544
UniProt
neXtProt
Antibodypedia	ERCC6-PGBD3 antibodies

PROTEIN BROWSER

ERCC6-PGBD3-001	ERCC6-PGBD3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ERCC6-PGBD3-001 ENSP00000423550 ENST00000515869	E7EV46 [Direct mapping] Protein ERCC6-PGBD3 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all		1061 aa 119.5 kDa	No	0
ERCC6-PGBD3-002 ENSP00000387966 ENST00000447839	E7EV46 [Direct mapping] Protein ERCC6-PGBD3 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all		1061 aa 119.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.