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TUBB3

GENERAL INFORMATION

Gene name

 TUBB3

Gene description

 Tubulin, beta 3 class III

Protein class

 Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (SCLC-21H)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, most abundant in CNS, and peripheral nerves.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA043640 , HPA046280
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043640
HPA046280

GENE INFORMATION

Gene name

 TUBB3 (HGNC Symbol)

Synonyms

 beta-4, CFEOM3, CFEOM3A, FEOM3

Description

 Tubulin, beta 3 class III (HGNC Symbol)

Entrez gene summary

 This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Oct 2010]

Chromosome

 16

Cytoband

 q24.3

Chromosome location (bp)

 89921392 - 89938761

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000258947 (version 83.38)

Entrez gene

 10381

UniProt

 Q13509 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13509

Antibodypedia

 TUBB3 antibodies

PROTEIN BROWSER
TUBB3-001
TUBB3-002
TUBB3-003
TUBB3-004
TUBB3-005
TUBB3-010
TUBB3-011
TUBB3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBB3-001
ENSP00000320295
ENST00000315491
Q13509 [Direct mapping]
Tubulin beta-3 chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007017 [microtubule-based process]
GO:0007067 [mitotic nuclear division]
GO:0007411 [axon guidance]
GO:0015630 [microtubule cytoskeleton]
GO:0030182 [neuron differentiation]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0042277 [peptide binding]
GO:0043025 [neuronal cell body]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
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 450 aa
50.4 kDa 		No 0
TUBB3-002
ENSP00000451617
ENST00000554444
Q13509 [Direct mapping]
Tubulin beta-3 chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007017 [microtubule-based process]
GO:0007411 [axon guidance]
GO:0030425 [dendrite]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0070062 [extracellular exosome]
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 378 aa
42.4 kDa 		No 0
TUBB3-003
ENSP00000452166
ENST00000556565
G3V542 [Direct mapping]
Tubulin beta-3 chain
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Predicted intracellular proteins
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GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 46 aa
5 kDa 		No 0
TUBB3-004
ENSP00000450538
ENST00000555810
G3V2A3 [Direct mapping]
Tubulin beta-3 chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 189 aa
20.7 kDa 		No 0
TUBB3-005
ENSP00000452554
ENST00000555576
G3V5W4 [Direct mapping]
Tubulin beta-3 chain
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Predicted intracellular proteins
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 97 aa
10.8 kDa 		No 0
TUBB3-010
ENSP00000450822
ENST00000554336
G3V2R8 [Direct mapping]
HCG1983504, isoform CRA_e; Tubulin beta-3 chain
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Predicted intracellular proteins
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GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 118 aa
13.6 kDa 		No 0
TUBB3-011
ENSP00000450765
ENST00000553967
G3V2N6 [Direct mapping]
HCG1983504, isoform CRA_d; Tubulin beta-3 chain
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Predicted intracellular proteins
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
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 164 aa
18.3 kDa 		No 0
TUBB3-201
ENSP00000485859
ENST00000625617
G3V3R4 [Direct mapping]
HCG1983504, isoform CRA_c; Tubulin beta-3 chain
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   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 148 aa
16.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.